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Understanding Cannabis Series: The Endocannabinoid System

October 16th, 2020
Understanding Cannabis Series: The Endocannabinoid System

The Endocannabinoid System (ECS) is an internal biological system that all mammals have. The ECS’s main priority is to maintain homeostasis, which is when all systems are balanced and harmonious. The ECS is made up of three separate parts: Cannabinoid receptors, Endocannabinoids, and Metabolic enzymes.

Let's take a closer look at each of these separate parts.


The cannabinoid receptors are a big part of cellular response. They essentially sit on the outside of the cell and transmit information to the inside of the cell. While there are more receptors, the most widely studied and well known are the CB1 and CB2 receptors. CB1 receptors are generally found in the brain and the central nervous system and are the cannabinoid receptors that are responsible for interacting with Tetrahydrocannabinol (THC) and making you feel what we all typically refer to as “high”. CB2 receptors are usually found in the extremities, however, both CB1 and CB2 receptors can be found throughout the entire body.


While the most famous Cannabinoids are THC and CBD, these are just two of hundreds of a class of compounds called Phytocannabinoids, meaning, produced by plants. Endocannabinoids are similar to plant cannabinoids in that they bind to receptors however, endocannabinoids are unique because they are produced by your body naturally. The two major endocannabinoids are anandamide and 2-AG and these are produced by your body on an on-demand basis. Your body doesn't store them, you use them as needed.


Metabolic enzymes are the ECS clean up crew. They work to efficiently break down and dispose of endocannabinoids once they’ve been used. This efficiency is what distinguishes the endocannabinoid system from other neurotransmitters which can hang around the body beyond the initial need. The two major metabolic enzymes are called FAAH and MAGL.

-FAAH (Fatty acid amide hydrolase) breaks down anandamide.

-MAGL (Monoacylglycerol lipase) breaks down 2-AG.


THC binds to both the CB1and CB2 receptors where it can affect such processes as your appetite, memory or sleep patterns for example. As CB1 Receptors are the main target of THC binding, scientists believe that the interaction between the two is the primary source for the sensations of intoxication. The interaction between THC and CB1 receptors also influences the perception of pain which is likely why many patients report relief from symptoms of chronic pain when using medical cannabis.

Interestingly researchers suggest that the phytocannabinoid cannabidiol (CBD) doesn’t bind to either the CB1 or CB2 receptors but is thought to work to modify the receptors' ability to bind to cannabinoids. Have you ever heard that taking CBD to counteract the effects of a too-strong THC dose can be helpful? That’s because CBD can weaken the CB receptors’ ability to bind to THC, thereby modulating excess cannabinoid activity in the brain. This can help reduce anxiety associated with THC. It’s important to note that many variables come into play with individual experiences including your unique biological makeup and genetics, the ratio of CBD/THC taken, the intensity of the anxiety, and even the sort of products you’ve used. 

While there is still much to learn and understand about the human ECS, researchers have identified a range of functions that are regulated by it, including but not limited to:

  • sleep
  • mood
  • appetite
  • memory
  • reproduction and fertility
  • Cardiovascular system function
  • Bone growth
  • Inflammation and immune system responses
  • Chronic pain response


This website provides general information and discussions about cannabis and related subjects. The information and other content provided in this website, or in any linked materials, are not intended and should not be construed as medical advice, nor is the information a substitute for professional medical expertise or treatment.

If you have a medical concern, you should consult with your healthcare practitioner or seek other professional medical treatment. We do not ever recommend that you disregard professional medical advice or delay in seeking out such advice because of something that have read on this blog or in any linked materials. If you think you may have a medical emergency, call your doctor or dial 911 immediately.

The opinions and views expressed on this blog and website have no relation to those of any academic, hospital, health practice or other institution.

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